Hm. It's a bit of a head-scratcher then. But if that family had them for years without adding new blood, they're definitely inbred, and maybe that is contributing to the problem (if not downright causing it). Some of the fish in the photos look like they have a curved spine, which can be either a result of the wasting disease, or caused by poor breeding. Ideally, such fish shouldn't be allowed to reproduce anymore, because it weakens the gene pool of the entire species. I don't know if bad genetics are causing the disease in your case, but they're definitely not helping. Fish tuberculosis (mycobacteriosis) could also explain some of the symptoms, including the knife-backed appearance of some of your fish (this one can transmit to humans so to be on the safe side it might be a good idea to use gloves when working around the tank). But if it's TB the fish would probably show some other symptoms, skin abnormalities, dropsy, trouble swimming etc. And it doesn't really explain why the females are more severely affected than the males. So it might just as well be something else. I also found a YouTube video that claims that the kind of wasting disease you're describing can happen in fry and females that have recently given birth, and the recommended treatment is to give them medicated food or antibiotics. Keep in mind that this came from a random YT video though, so I'd take it with a pinch of salt ? Have you tried Levamisole? I've heard some people use it to treat wasting disease caused by parasitic nematodes. Maybe for some reason the previous medication your used "missed" it. But if antiparasitics don't work, then maybe it's bacterial & you can try a broad-spectrum antibiotic (in a separate container, you don't want to kill off the beneficial bacteria). I'd also feed them a more varied diet, with different high quality foods - good nutrition is as important as clean water when it comes to keeping a fish's immune system healthy.
I'm sorry I can't be of any more help rn. If I find any more information I'll let you know.