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I have no idea what the dose is on the bottle but if the dose rate is 500ml for 5000gallons of water. Just knock off the 0s at the end to get a lower dose rate.

500ml per 5000gallons
50ml per 500gallons
5ml per 50gallons
1 ml per 10 gallons

If you need to reduce that further, add 1ml of distilled water to 1ml of the dechlorinator and it will be
1ml per 5gallons

There's about 16 drops per ml, depending on the size of the hole on the dispenser.
 
I just read another post on Seachem website that said mixing Safe ahead of time will lose it’s strength within a week once mixed.
Yes I have read all those, but my personal experience is quite different.

I have been using the mix I described in are 200 gal pond for over 3 years with out a single fish loss. This includes some 100% water changes during the hot summer months.

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