I have multiple Fluval canister filters and my biggest beef is the cleaning.
I have a 207 with the UV attachment for my 38 gallon saltwater tank. As the tank has live rock and sand, the filter is more mechanical - though I have some cone shaped sponges growing in there. I clean it about every 6-8 months.
I have the big boys as well. My 120 has 2 FX4 canisters on it. I have had an issue with the one after I clean it, it needs to be messed with; motor/impeller needs to be removed and cleaned. I purchased an extra motor because I thought it died, but haven't had to use it yet
My 125 has a FX4 and FX6. When I clean the filters it's brutal due to the amount of sponges in these filters. My 125 had a considerable amount of plecos in it so the amount of sludge that accumulates is significant. It would take close to an hour to clean the sponges in the FX6. I never clean both filters the same day, usually the next week.
My favorite part with the big guys is that it's supposed to have a sensor to restart but I will come back an hour or so later and it's still off. Usually unplugging it get it to start the right way.
I am looking forward to building my own tank with a wetlands filter; no more unhooking, lifting a full filter, cleaning multiple sludge filled sponges, refilling and carrying back to re hook up and turn the filters back on for the junk in the tubbing to fill the tank with junk-cause you just cleaned the tank...
The HOB filters do the same, unless you take the whole thing off and clean the unit as well as the media. I don't do that every time, but when you don't the filter expells all that junk right back into the tank.