The effect of Prime or similar products is about the same. When you use them they take the chloramine and break the chemical bonds to produce chlorine and ammonia. In the case of chemical treatments like Prime, or similar products, they result in some neutralized chlorine and a finite amount of ammonia which they deal with by making it less likely to impact the fish. The end result is that the contaminants resulting from dechlorinators means that the dechlorinators cause no real problems with our fish. Where does that leave you? The result is that a true world hobbyist is no more likely to have trouble with shipped fish than with LFS bred fish.