I have a Fluval 205 canister filter, and I basically have four media positions:
Position 1: The water "falls" into the left half of the canister via gravity, and that entire 12" (approx). depth is covered by mechanical foam media. These foams pieces are easy to rinse in buckets of tank water.
Positions 2, 3, and 4: The water is then pumped up the right half of the canister through three baskets: (the water goes through in the order basket 1, then 2, then 3)
Basket 1 = Fluval "pre-filter" cylinder pellets: these primarily act as mechanical filtration, according to the instructions. Similar to what Waterdrop said about changing the direction of the water, slowing it down, and making the solid waste settle out.
Baskets 2 & 3: In these baskets I have Biomax ceramic rings specifically designed to grow bacteria, and also a different brand of small bio-pellets that are in mesh bags (I had them on hand and wanted to add more bio-capacity to the baskets).
If I ever needed to filter out medication used in the tank, I would then throw in a carbon media in basket 1 in place of the pre-filter.
That was a lot of words to say that from what I have read, you really don't need chemical media except for special circumstances, and you generally want mechanical media to come before bio-media. This keeps solid waste from mucking up the bacteria colonies that we want to keep happy and un-mucked!!