rabbut
I don't bite, all that often...
Humm, you've added the meds now by the sounds of it, so mebe I'm a it late...
No signs of HITH in the photos that I can see. The male's weight looks fine to me also
The swelling could be consistant with Bacteria, parasites and organ failure. I personally don't think bacteria. I can't convince myself that the eye on the male was abnormal TBH, there is no haemorrhaging (blood under the skin) and the scales are not raised as you would expect with dropsey. I doubt you have the equipment for autopsies, and have likely disposed of the bodies now, so you cannot really confirm or rule out bacteria as a cause. The Interpet Anti-internal bacteria med is really strong though, and can wipe Bio-filters IME, so I'd only use it if you are 100% certain that your problem is bacterial
Parasites are a possibility, but again cannot be a confirmed/ruled-out cause without autopsy, unless you can confidently say that the long stringy white thing on the female was definitely a worm of some form?
Organ failure is another possibility. It can cause the swellings without raised scales or other symptoms, or with the stringy poo. It is usual to come across, especially two together, unless there is an underlying cause. One such cause would be poisoning. For some unknown reason, my gut feeling is screaming at me that this may be the cause.
I would probably do a large (50% ish) water change, using your tried and trusted tap supply before the Python, and have the water at your tap tested by the local water board. Just tell them you suspect that there may be a water quality problem with that tap, and they will send someone out with a full lab-grade test kit and test for pretty much everything under the sun before leaving you a nice report. Any issues will be fixed for you if found. Otherwise, you can rule out the change of water supply as a likely cause
All the best
Rabbut
No signs of HITH in the photos that I can see. The male's weight looks fine to me also

The swelling could be consistant with Bacteria, parasites and organ failure. I personally don't think bacteria. I can't convince myself that the eye on the male was abnormal TBH, there is no haemorrhaging (blood under the skin) and the scales are not raised as you would expect with dropsey. I doubt you have the equipment for autopsies, and have likely disposed of the bodies now, so you cannot really confirm or rule out bacteria as a cause. The Interpet Anti-internal bacteria med is really strong though, and can wipe Bio-filters IME, so I'd only use it if you are 100% certain that your problem is bacterial

Parasites are a possibility, but again cannot be a confirmed/ruled-out cause without autopsy, unless you can confidently say that the long stringy white thing on the female was definitely a worm of some form?
Organ failure is another possibility. It can cause the swellings without raised scales or other symptoms, or with the stringy poo. It is usual to come across, especially two together, unless there is an underlying cause. One such cause would be poisoning. For some unknown reason, my gut feeling is screaming at me that this may be the cause.
I would probably do a large (50% ish) water change, using your tried and trusted tap supply before the Python, and have the water at your tap tested by the local water board. Just tell them you suspect that there may be a water quality problem with that tap, and they will send someone out with a full lab-grade test kit and test for pretty much everything under the sun before leaving you a nice report. Any issues will be fixed for you if found. Otherwise, you can rule out the change of water supply as a likely cause

All the best
Rabbut

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