The thing is that whats not toxic to us can in fact be toxic to fish, or can turn toxic if left under water for a great deal of time. It takes a lot of money and a great deal of time to determine if something is toxic or not, just putting some goldfish in with the paint won't tell you a whole lot.
Though fish toxicity is a common route to measure a substance's toxicity. Zebra Danios are a typical test subject, though many other fish have been used. In terms of time and money, what opcn is saying is that the test results need to be statistically significant ( see http
