Depends on the flow past them. If you run them constantly on a small tank they'll overflow and you'll waste a lot of CO2. The bell diffusers basically work by having a surface area of CO2 in contact with the water. If the water is moving then you can get away with a low flow, but you'll struggle with it overfilling.
You could always get a small diffuser for them instead of the bell, but I've found the regulator on them difficult to get fine adjustments on as well, as they're designed for the on off of the bell.