Thanks for all the information, you guys....I think that it wouldn't hurt to give the Clout and epsom salts a try first. It'll mean putting the big guy back in the 20g tank again and he will hate that but if it helps, it'll be worth it. At the worst, nothing will change and I'll just have a grumpy oscar on my hands.
After trying the Clout I guess I will put him back in the 180 and wait and see what happens. If he seems to take a turn for the worse, my fiance and I will reconsider trying the needle method.
But we can't do it ourselves...we'll have to try to find someone to do it for us. We're heading up to one of our favorite LFS's (Old Orchard in Skokie, maybe Tolak knows what I'm talking about) soon and while we're there, we'll ask the people there if they have heard of using hypodermic needles on fish with tumors and see if they know anything about it.
My mom works for a vet's office as a receptionist so I'll ask her to ask her boss about it as well. He specializes in exotic animals but I don't know if he has had experience with fish.
I've found something interesting--it seems like when the 180's temperature is high (85, as it was when I first took him out of the water), One-Eye has more trouble staying upright. But when it's on the cool side (like 77), he doesn't have as much of a problem. Is it a coincidence or could the temperature really affect something like that?
Tolak--When I put One-Eye back in the 20 for medication, should I put him through another round of Maracyn I & II plus epsom salts first, then start on the Clout plus salts once the antibiotics have finished their course?