definately need more info before we can make a diagnosis, can you supply the following info please, give as much details as you can, it's hard to diagnose over the internet so tell us everything you can about the tank
what size is the tank?
what fish do (did) you have in it, how old were they and what size?
what equipment are you running on the tank?
Do you test the water, if so what are your latest test readings for pH, ammonia, nitrite and nitrate?
What test kit are you using?
How old is the tank?
How did you cycle the tank?
What is your maintenance routine?
My initial guess is at old tank syndrome, this is where a tank has been running for some time but not received regular maintenance, when you do a water change the shock of the improved conditions is enough to kill the fish.