you can over vacuum the gravel. too much and you remove the bacteria. as to water changes in general i wouldn't do more than 3 a week (25% each time) but only if you have a problem. ie high nitrate etc..
normally 25% once a week will be fine. why on earth you'd want to do more is beyond me. it's not the most rewarding part of the hobby.
Just stick with 25% once a week and you'll be fine.. like Jimbooo said, too many vacs during changes and you remove the bacteria. Straight water changes aren't so bad, but why do more if you don't have to?