I've had a repeatedable issues with caribsea moonshine and i believe it is because it is extremely fine (when i say repeatable i mean i ran tests in smaller aquariums after i encountered a problem in a 29 and i could reproduce it easily. I've never had an issue with hth pool fitler sand and estes stoney river and i made up a term 'breathable'.I've never had aerobic pockets of gas, if that's what you mean. Any substrate under decor will have anaerobic bacteria in it, but that's not a bad thing as they'll help break down waste that gets in the substrate.
The stuff that i produced in moonshine was quite deadly killing plants and to a degree animal life (sulfur smell). I got rid of the stuff and the issue went away. Hence crystal river is the finest substrate i recommend with the presumption anything finer that is deep in a planted aquarium is going to cause issue.
The funny thing is moonshine (or is it moonlight?) doesn't pack and i love the stuff 'cept for the gas pocket issue.
You also have to understand that there are different bacteria that produce gas pocket and some are quite harmless or the gas is quite harmless - in shallower aquarium i would get nitrogen instead of sulfur.