Not in the same way as gravel, if you tried using a gravel vac it would all get sucked out!
All the fish waste will sit on top, so the surface is the only area that needs cleaning. I personally use a simple piece of tubing to clean mine, once you start siphoning just wave the pipe around over any dirt and it will get sucked up leaving the sand in place. Dont get too close though or you'll end up with sand in your bucket