If you take out the parents once the fry are free swimming they will breed twice a month. I would take out the male once the fry are free swimming which will be around 3-4 days. You can leave the female in there for another 2 weeks, then take her out. I have left the female in there forever and she still takes care of them, but I have had that plan bit in the backside time to time. So the safe bet is to take her out after a month with the fry.