Size of tank in gallons or litres.
How many fish and which type.
Water stats in ammonia, nitrite, nitrate, and ph.
Is it possible to load a pic up onto the site.
Any redness to the white blister.
Are you sure it's a strand of cotton coming from the blister, and not a parasite.
Any signs of flicking and rubbing, excess mucas, darting, erratic swimming, laboured breathing.