Hi Shelly
I had a similar problem over a year ago, was such a pain, lost quite a few live-bearers, it didnt seem to affect non live-bearers. It also mostly affected the female live-bearers, although not exclusively.
I wouldn't like to say for sure its internal parasites, Wilder knows more about that and i am sure she'll post on this sometime today.
If it's internal parasites or it'ss strongly suspected, my preference is to move fish showing symptoms (the skinny's basically) - Do you have anything tank wise or evena big container you can set-up for affected fish?
As Wilder has correctly pointed out previously, this doesn't necessaeily negate the treatment of the tank as a whole, but i really do advise moving the fish, due to the below paragraph here
Side Issue - Generally i dont like moving sick fish, as i am sure it stresses them more, but with the "skinny's" i think stressing the fish a little and dealing the practical problems of moving the fish is worth it, due to the risk the fish poses to other fish in the main tank. Dont panic though, if one fish has internal parasites it doesnt necessarily mean other fish will catch it, obviously they might, buts its not automatic.
Shelly i am not advising this to you at the moment, but me personally, in my community tank, if i see a fish that has lost a lot of weight despite eating, i euthanise it.... for 3 reasons (A) never seen a guppy, platy, swordtail or molly recover from this despite different treatments and (B i dont want to increase the risk of a wipe out or other deaths in my main tank and © I certainly dont want a corpse in my tank (fish dies overnight or i cant find the body) that then gets eaten or partially eaten by other fish. I euthanise a bit quicker than some would, so i am in the minority here i am sure.
Fortunately i only had this with two or three fish in over a year (all LFS purchased platy's)
Do a bit of Google research on internal parasites, have a look about, also do some research on treatments such as "wormer plus", but Wilder will advise more.
I think but not sure...... generally speaking, many traditional over the counter fish meds are not hugely successful with internal parasites although Waterlife's Sterazin claims to treat for some internal parasites.
It might not be internal parasites for sure, but what you describe suggests it could be.
Wilder's gonna ask anyway, so best get the info ready now if you can.......
EDIT: you already did most of this!!!!!!!
take size
total fish in tank
any recent water readings regardnig ammonia, nitrite, nitrate, pH
i would like to add...
any new purchases of fish recently? however in my experience not totally significant, i've had LFs purchased live-bearers get the "Skinny's" 6-9 months after i got them with no other fish in the tank affected.
My own personal theory, is that LFS purchased guppies, mollies, platies and swordtails have weaker immune systems and internal problems are much more likely to happen than with any other fish.