Nope not at all, but it also depends on what type of set up.
Having high turnover rate stops crap settleing, helps prevent cyano. Alows you to keep SPS corals if params and lighting are coreect.
I had well over 70x in my old tank at one point. One thing to think about though, LPS corals dont do so great in areas of really high flow so you may need to move them around a bit til they find somewhere that suits them. Also some fish dont do so well in huge amounts of flow e.g boxfish. Stuff like clowns and most other common marine fish are strong swimmers though.
Out of interest how many pumps is this 42X from?