I had a sore on my hand once that would not heal. I also noticed lumps under my skin leading away from the sore and up my arm. I was working in a store with a lot of salt water tanks at the time, and I was doing a ton of maintenence. Old undergravel filters and lots of sediment in the tanks. The doctors diagnosed it as Tuberculosis of the lymph system, and determined the fish tanks were the only possible source of the bacteria. I had to go on six months of Isoniazid and Prednisone, and go to the doctors weekly for checkups. Their concern was that the infection was traveling up the lymph system towards the Heart. They said they had only heard of one other case in my part of the state. I was quite the celebrity among the doctors as all wanted to see the freak illness. I do think this was a special circumstance, one you would not likely find in a home tank. Of course as the time has passed, my hands are again constantly in the tanks, messing around. I always make sure I wash good afterwards.