CO2 does not change the ionic strength of the solution, adding baking soda(adds KH), a salt, will.
CO2 is not a salt.
While it can lower pH, it does not harm fish.
Baking soda when added rapidly, can kill your fish ansd causes a rise in pH that is permanent, CO2 gas when you stop adding it, causes the pH to climb back up.
Takes time for the fish to adapt to the new ionic salt bath. Too fast and it'll kill the fish.
Folks have been doing massive weekly water changes for decades now with CO2 and never seen any ill effects on highly sensitive livestock such as wild Altums, Discus, Apisto's etc.
Once you have fish/plants that have been getting large weekly water changes, the stability of the KH and the tank in general is very stable. Unless the tap water source etc changes dramatically, this allows the aquarist to have a better, cleaner tank with less interactions with organic processes(many of which you cannot test for specifically) that occur in aquariums.
Amano, myself, David Oliver, CAU and most scapers tend to do large frequent weekly or more in some cases) water changes and basic cleaning methods.
Regards,
Tom Barr