The issue here, I think, is how to keep nitrates lowest and many find that canisters are a bit harder to work with with regards to marines. Can you use them? Sure. But the canister would need attention and cleansing. Many contain cermics, noodles, etc...although, they can be removed.
Without a doubt, a sump, refugium, live rock and water pumps are excellent methods of filtration. LR provides biological and macroalgae ALSO provides chemical sorta by consuming nitrates. I cannot overemphasize the amazing help a refugium provides. My nitrates are at zero now for over a year plus since I got my chaeto cooking. As for other chemical, many create chambers in their sumps/refugiums where they can put their media (phosphate binders, etc.)
SH