The plant is not going to care much, being uprooted and replanted in sand. Plants will do better in a finer grain gravel or sand. Substrate-rooted plants will grow in most any substrate, though gravel large like this one can pose some issues. Biological activity occurs more effectively in sand (or a finer gravel). So there really are no down-sides.
As for cleaning, I tend not to touch the substrate much anyway, except sometimes in the open areas. Running the water changer just above the sand and stirring up the top level works well.